Mechanism of Chain Selection in the Assembly of Collagen IV: A Prominent Role for the α2 Chain*
نویسندگان
چکیده
Jamshid Khoshnoodi, Kristmundur Sigmundsson§, Jean-Philippe Cartailler, Olga Bondar, Munirathinam Sundaramoorthy and Billy G. Hudson Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, and §Novo Nordisk A/S, DK-2760 Måløv, Denmark Running Title: Mechanism of Collagen IV Assembly Address correspondence to: Jamshid Khoshnoodi and Billy G. Hudson, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-2372, Tel. 615 322-3352, Fax. 615 3437156; E-Mails: [email protected] and [email protected]
منابع مشابه
Mechanism of chain selection in the assembly of collagen IV: a prominent role for the alpha2 chain.
Collagens comprise a large superfamily of extracellular matrix proteins that play diverse roles in tissue function. The mechanism by which newly synthesized collagen chains recognize each other and assemble into specific triple-helical molecules is a fundamental question that remains unanswered. Emerging evidence suggests a role for the non-collagenous domain (NC1) located at the C-terminal end...
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